7PPM

SHP2 catalytic domain in complex with IRS1 (889-901) phosphopeptide (pSer-892, pTyr-896)

Summary for 7PPM

Entry DOI	10.2210/pdb7ppm/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 11,Tyrosine-protein phosphatase non-receptor type 11, Insulin receptor substrate 1, GLYCEROL, ... (4 entities in total)
Functional Keywords	shp2, irs1, phosphatase, phosphopeptide, insulin signaling, insulin receptor substrate 1, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	34391.59
Authors	Sok, P.,Zeke, A.,Remenyi, A. (deposition date: 2021-09-14, release date: 2022-09-07, Last modification date: 2024-01-31)
Primary citation	Zeke, A.,Takacs, T.,Sok, P.,Nemeth, K.,Kirsch, K.,Egri, P.,Poti, A.L.,Bento, I.,Tusnady, G.E.,Remenyi, A. Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling. Nat Commun, 13:5439-5439, 2022 Cited by PubMed: 36114179 DOI: 10.1038/s41467-022-32918-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.48 Å)

Structure validation