7PPM

SHP2 catalytic domain in complex with IRS1 (889-901) phosphopeptide (pSer-892, pTyr-896)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Tyrosine-protein phosphatase non-receptor type 11,Tyrosine-protein phosphatase non-receptor type 11	polymer	282	32629.9	1	UniProt (Q06124) Pfam (PF00102) In PDB	Homo sapiens (Human)	Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,SHP-2,Shp2,SH-PTP3,Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,SHP-2,Shp2,SH-PTP3
2	B	Insulin receptor substrate 1	polymer	13	1669.6	1	UniProt (P35568) In PDB	Homo sapiens	IRS-1
3	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4		water	water		18.0	124	Chemie (HOH)

Sequence modifications

A: 5 - 73 (UniProt: Q06124)

PDB	External Database	Details
Gly 1	-	expression tag
Ser 2	-	expression tag
Gly 3	-	expression tag
Ser 4	-	expression tag

A: 78 - 282 (UniProt: Q06124)

PDB	External Database	Details
Gly 74	-	linker
Ser 75	-	linker
Ser 76	-	linker
Gly 77	-	linker
Ser 213	Cys 459	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	34299.5
Non-Polymers*	Number of molecules	1
	Total formula weight	92.1
All*	Total formula weight	34391.6

*Water molecules are not included.