7POX

TNKS2 in complex with OM-1700, treated with H2O2

This is a non-PDB format compatible entry.

Summary for 7POX

• Entry DOI: 10.2210/pdb7pox/pdb
• Descriptor: Poly [ADP-ribose] polymerase tankyrase-2, N-[3-[5-(5-ethoxypyridin-2-yl)-4-(2-fluorophenyl)-1,2,4-triazol-3-yl]cyclobutyl]pyridine-2-carboxamide (3 entities in total)
• Functional Keywords: zinc, coordination, enzyme, poly-adp-ribosylation, inhibitor, h2o2, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 50573.16

Authors

Sowa, S.T.,Lehtio, L. (deposition date: 2021-09-10, release date: 2022-05-04, Last modification date: 2024-01-31)

• Primary citation: Sowa, S.T.,Lehtio, L.; The zinc-binding motif in tankyrases is required for the structural integrity of the catalytic ADP-ribosyltransferase domain.; Open Biology, 12:210365-210365, 2022; PubMed: 35317661; DOI: 10.1098/rsob.210365

Experimental method

X-RAY DIFFRACTION (2.5 Å)