7PNL

Complex between monomolecular human telomeric G-quadruplex and a sulfonamide derivative of the natural alkaloid Berberine

Summary for 7PNL

• Entry DOI: 10.2210/pdb7pnl/pdb
• Descriptor: G-guadruplex DNA (23-mer), POTASSIUM ION, 4-[[1-[3-[(17-methoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{15,20}]henicosa-1(21),2(10),3,8,13,15,17,19-octaen-16-yl)oxy]propyl]triazol-4-yl]methoxy]benzenesulfonamide, ... (4 entities in total)
• Functional Keywords: drug-dna complex, telomeric g-quadruplex, dna
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 8638.31

Authors

Bazzicalupi, C.,Gratteri, P.,Petreni, A.,Nocentini, A. (deposition date: 2021-09-07, release date: 2022-09-21, Last modification date: 2024-01-31)

• Primary citation: Bazzicalupi, C.,Gratteri, P.,Petreni, A.,Nocentini, A.,Supuran, C.,Randazzo, A.; Complex between monomolecular human telomeric G-quadruplex and a sulfonamide derivative of the natural alkaloid Berberine; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.83 Å)