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7PCI

BurG (holo) in complex with hydroxypyruvate-enol (8): Biosynthesis of cyclopropanol rings in bacterial toxins

Summary for 7PCI
Entry DOI10.2210/pdb7pci/pdb
Related6AQJ
DescriptorKetol-acid reductoisomerase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, MAGNESIUM ION, ... (6 entities in total)
Functional Keywordspathogens, natural products, toxins, biosynthesis, catalysis, lyase
Biological sourceBurkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)
Total number of polymer chains1
Total formula weight39601.88
Authors
Trottmann, F.,Ishida, K.,Ishida, M.,Kries, H.,Groll, M.,Hertweck, C. (deposition date: 2021-08-03, release date: 2022-08-10, Last modification date: 2024-01-31)
Primary citationTrottmann, F.,Ishida, K.,Ishida-Ito, M.,Kries, H.,Groll, M.,Hertweck, C.
Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead.
Nat.Chem., 14:884-890, 2022
Cited by
PubMed: 35906404
DOI: 10.1038/s41557-022-01005-z
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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