7P4E

Crystal structure of PPARgamma in complex with compound FL217

Summary for 7P4E

Entry DOI	10.2210/pdb7p4e/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, ~{N}-[[4-(cyclopropylsulfonylamino)-2-(trifluoromethyl)phenyl]methyl]-1-[(3-fluorophenyl)methyl]indole-5-carboxamide, SULFATE ION, ... (5 entities in total)
Functional Keywords	complex, structural genomics, structural genomics consortium, sgc, dna binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	32681.81
Authors	Ni, X.,Lillich, F.,Proschak, E.,Chaikuad, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2021-07-11, release date: 2022-07-06, Last modification date: 2024-01-31)
Primary citation	Lillich, F.F.,Willems, S.,Ni, X.,Kilu, W.,Borkowsky, C.,Brodsky, M.,Kramer, J.S.,Brunst, S.,Hernandez-Olmos, V.,Heering, J.,Schierle, S.,Kestner, R.I.,Mayser, F.M.,Helmstadter, M.,Gobel, T.,Weizel, L.,Namgaladze, D.,Kaiser, A.,Steinhilber, D.,Pfeilschifter, W.,Kahnt, A.S.,Proschak, A.,Chaikuad, A.,Knapp, S.,Merk, D.,Proschak, E. Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor gamma Agonists/Soluble Epoxide Hydrolase Inhibitors. J.Med.Chem., 64:17259-17276, 2021 Cited by PubMed: 34818007 DOI: 10.1021/acs.jmedchem.1c01331 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation