7P41

Crystal Structure of human mARC1 A165T Variant

Summary for 7P41

• Entry DOI: 10.2210/pdb7p41/pdb
• Related: 6FW2
• Descriptor: Mitochondrial amidoxime-reducing component 1,Endolysin,Mitochondrial amidoxime-reducing component 1, oxidanyl(oxidanylidene)molybdenum, PHOSPHONIC ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER, ... (6 entities in total)
• Functional Keywords: molybdenum cofactor, molybdenum enzyme, molybdopterin, pyranopterin, marc, metal binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 51388.16

Authors

Struwe, M.A.,Scheidig, A.J. (deposition date: 2021-07-09, release date: 2021-08-18, Last modification date: 2024-01-31)

Primary citation

Struwe, M.A.,Clement, B.,Scheidig, A.
Letter to the editor: The clinically relevant MTARC1 p.Ala165Thr variant impacts neither the fold nor active site architecture of the human mARC1 protein.
Hepatol Commun, 6:3277-3278, 2022

PubMed Abstract: A study recently published in Hepatology Communications provided insights into a variant of MTARC1 protein, which conveys protection against liver disease. Here, we report a crystal structure of the variant protein at near-atomic resolution and compare it to the structure of the wildtype protein.

PubMed: 35560545
DOI: 10.1002/hep4.1984

Experimental method

X-RAY DIFFRACTION (1.6 Å)