7OXB

Crystal structure of EGFR double mutant (T790M/L858R) in complex with compound 6.

Summary for 7OXB

• Entry DOI: 10.2210/pdb7oxb/pdb
• Descriptor: Epidermal growth factor receptor, 2-[2-(3-methoxyphenyl)pyrimidin-4-yl]-1'-prop-2-enoyl-spiro[5,6-dihydro-1~{H}-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-4-one (3 entities in total)
• Functional Keywords: kinase, inhibitor, egfr, mutant, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 37767.77

Authors

Collie, G.W. (deposition date: 2021-06-22, release date: 2021-10-20)

• Primary citation: Hoogenboom, N.,Demont, D.,de Zwart, E.,Verkaik, S.,Emmelot, M.,van de Kar, B.,Kaptein, A.,Barf, T.; Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors".; Bioorg.Med.Chem.Lett., :128406-128406, 2021; PubMed: 34624491; DOI: 10.1016/j.bmcl.2021.128406

Experimental method

X-RAY DIFFRACTION (2.56 Å)