7OXB
Crystal structure of EGFR double mutant (T790M/L858R) in complex with compound 6.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 326 | 37324.3 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (A) | 2-[2-(3-methoxyphenyl)pyrimidin-4-yl]-1'-prop-2-enoyl-spiro[5,6-dihydro-1~{H}-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-4-one | non-polymer | 443.5 | 1 | Chemie (35Z) | |||
| 3 | C (A) | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A: 696 - 1020 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Met 695 | - | initiating methionine |
| Met 790 | Thr 790 | variant |
| Arg 858 | Leu 858 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37324.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 443.5 | |
| All* | Total formula weight | 37767.8 |
