7OWB

Chimeric carminomycin-4-O-methyltransferase (DnrK) with a region from 10-hydroxylase CalMB

7OWB の概要

• エントリーDOI: 10.2210/pdb7owb/pdb
• 関連するPDBエントリー: 1TW2
• 分子名称: Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing protein, methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
• 機能のキーワード: carminomycin-4-o-methyltransferase variant; chimeragenesis; aclacinomycin 10-hydroxylase, biosynthetic protein
• 由来する生物種: Streptomyces peucetius; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41258.71

構造登録者

Dinis, P.,MetsaKetela, M. (登録日: 2021-06-17, 公開日: 2022-07-13, 最終更新日: 2024-02-07)

• 主引用文献: Dinis, P.,Tirkkonen, H.,Wandi, B.N.,Siitonen, V.,Niemi, J.,Grocholski, T.,Metsa-Ketela, M.; Evolution-inspired engineering of anthracycline methyltransferases.; Pnas Nexus, 2:pgad009-pgad009, 2023; PubMed: 36874276; DOI: 10.1093/pnasnexus/pgad009

実験手法

X-RAY DIFFRACTION (2.45 Å)