7OUP

Structure of human DPP3 in complex with a hydroxyethylene transition state peptidomimetic

Summary for 7OUP

• Entry DOI: 10.2210/pdb7oup/pdb
• Descriptor: Dipeptidyl peptidase 3, ((2R,4S,5S)-5-((S)-2-amino-3-methylbutanamido)-2-benzyl-4-hydroxy-6-methylheptanoyl)-L-prolyl-L-tryptophan, ZINC ION, ... (6 entities in total)
• Functional Keywords: inhibitor, complex, peptidase, zinc-hydrolase, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 83394.49

Authors

Kumar, P.,Reithofer, V.,Gruber, K. (deposition date: 2021-06-12, release date: 2021-08-11, Last modification date: 2024-01-31)

• Primary citation: Ivkovic, J.,Jha, S.,Lembacher-Fadum, C.,Puschnig, J.,Kumar, P.,Reithofer, V.,Gruber, K.,Macheroux, P.,Breinbauer, R.; Efficient Entropy-Driven Inhibition of Dipeptidyl Peptidase III by Hydroxyethylene Transition-State Peptidomimetics.; Chemistry, 27:14108-14120, 2021; PubMed: 34314529; DOI: 10.1002/chem.202102204

Experimental method

X-RAY DIFFRACTION (2.65 Å)