7OUP
Structure of human DPP3 in complex with a hydroxyethylene transition state peptidomimetic
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Dipeptidyl peptidase 3 | polymer | 737 | 82617.9 | 1 | UniProt (Q9NY33) Pfam (PF03571) In PDB | Homo sapiens (Human) | Dipeptidyl aminopeptidase III,Dipeptidyl arylamidase III,Dipeptidyl peptidase III,DPP III,Enkephalinase B |
| 2 | F | ((2R,4S,5S)-5-((S)-2-amino-3-methylbutanamido)-2-benzyl-4-hydroxy-6-methylheptanoyl)-L-prolyl-L-tryptophan | polymer | 4 | 647.8 | 1 | synthetic construct | ||
| 3 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | A | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 5 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | water | water | 18.0 | 73 | Chemie (HOH) |
Sequence modifications
A: 1 - 737 (UniProt: Q9NY33)
| PDB | External Database | Details |
|---|---|---|
| Ala 451 | Glu 451 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 83265.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 128.8 | |
| All* | Total formula weight | 83394.5 |
