7OKP

Crystal structure of mouse CARM1 in complex with histone H3_13-22 K18 acetylated

7OKP の概要

• エントリーDOI: 10.2210/pdb7okp/pdb
• 分子名称: Histone-arginine methyltransferase CARM1, Histone H3.3, MALONATE ION, ... (5 entities in total)
• 機能のキーワード: protein arginine n-methyltransferase, prmt, carm1, transition state mimics, transcription
• 由来する生物種: Mus musculus (Mouse); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 174119.29

構造登録者

Marechal, N.,Cura, V.,Troffer-Charlier, N.,Bonnefond, L.,Cavarelli, J. (登録日: 2021-05-18, 公開日: 2021-10-27, 最終更新日: 2024-01-31)

• 主引用文献: Zhang, Y.,Marechal, N.,van Haren, M.J.,Troffer-Charlier, N.,Cura, V.,Cavarelli, J.,Martin, N.I.; Structural Studies Provide New Insights into the Role of Lysine Acetylation on Substrate Recognition by CARM1 and Inform the Design of Potent Peptidomimetic Inhibitors.; Chembiochem, 22:3469-3476, 2021; PubMed: 34569136; DOI: 10.1002/cbic.202100506

実験手法

X-RAY DIFFRACTION (2.2 Å)