7OK3
Crystal Structure of KRasG13C in Complex with Nucleotide-based Covalent Inhibitor edaGDP
Summary for 7OK3
| Entry DOI | 10.2210/pdb7ok3/pdb |
| Descriptor | Isoform 2B of GTPase KRas, edaGDP (3 entities in total) |
| Functional Keywords | gtpase, ras, kras, krasg13c, nucleotide analogues, edagdp, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 20019.24 |
| Authors | Goebel, L.,Mueller, M.P.,Rauh, D. (deposition date: 2021-05-17, release date: 2022-08-03, Last modification date: 2024-02-07) |
| Primary citation | Goebel, L.,Kirschner, T.,Koska, S.,Rai, A.,Janning, P.,Maffini, S.,Vatheuer, H.,Czodrowski, P.,Goody, R.S.,Muller, M.P.,Rauh, D. Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors. Elife, 12:-, 2023 Cited by PubMed: 36972177DOI: 10.7554/eLife.82184 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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