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7OGY

C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1-benzyl-N5-cyclopropyl-N3-methyl-1H-pyrazole-3,5-dicarboxamide

This is a non-PDB format compatible entry.
Summary for 7OGY
Entry DOI10.2210/pdb7ogy/pdb
Related7OE4 7OE5 7OE6
DescriptorBromodomain-containing protein 2, 1,2-ETHANEDIOL, N5-cyclopropyl-N3-methyl-1-(phenylmethyl)pyrazole-3,5-dicarboxamide, ... (5 entities in total)
Functional Keywordsinhibitor, bromodomain, nuclear protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight14085.19
Authors
Chung, C. (deposition date: 2021-05-07, release date: 2021-07-28, Last modification date: 2021-08-25)
Primary citationSeal, J.T.,Atkinson, S.J.,Bamborough, P.,Bassil, A.,Chung, C.W.,Foley, J.,Gordon, L.,Grandi, P.,Gray, J.R.J.,Harrison, L.A.,Kruger, R.G.,Matteo, J.J.,McCabe, M.T.,Messenger, C.,Mitchell, D.,Phillipou, A.,Preston, A.,Prinjha, R.K.,Rianjongdee, F.,Rioja, I.,Taylor, S.,Wall, I.D.,Watson, R.J.,Woolven, J.M.,Wyce, A.,Zhang, X.P.,Demont, E.H.
Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors.
J.Med.Chem., 64:10772-10805, 2021
Cited by
PubMed: 34255512
DOI: 10.1021/acs.jmedchem.1c00365
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.602 Å)
Structure validation

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