7OE6
C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH N4-hydroxycyclohexyl-N2-methyl-5-phenylethyl-furan-2,4-dicarboxamide
This is a non-PDB format compatible entry.
Summary for 7OE6
Entry DOI | 10.2210/pdb7oe6/pdb |
Related | 7OE4 7OE5 |
Descriptor | Bromodomain-containing protein 2, 2N-methyl-4N-(4-oxidanylcyclohexyl)-5-[(1S)-1-phenylethyl]furan-2,4-dicarboxamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | inhibitor, bromodomain, nuclear protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 13927.04 |
Authors | Chung, C. (deposition date: 2021-05-01, release date: 2021-07-28, Last modification date: 2024-05-01) |
Primary citation | Seal, J.T.,Atkinson, S.J.,Bamborough, P.,Bassil, A.,Chung, C.W.,Foley, J.,Gordon, L.,Grandi, P.,Gray, J.R.J.,Harrison, L.A.,Kruger, R.G.,Matteo, J.J.,McCabe, M.T.,Messenger, C.,Mitchell, D.,Phillipou, A.,Preston, A.,Prinjha, R.K.,Rianjongdee, F.,Rioja, I.,Taylor, S.,Wall, I.D.,Watson, R.J.,Woolven, J.M.,Wyce, A.,Zhang, X.P.,Demont, E.H. Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors. J.Med.Chem., 64:10772-10805, 2021 Cited by PubMed: 34255512DOI: 10.1021/acs.jmedchem.1c00365 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.762 Å) |
Structure validation
Download full validation report