7OE6

C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH N4-hydroxycyclohexyl-N2-methyl-5-phenylethyl-furan-2,4-dicarboxamide

This is a non-PDB format compatible entry.

Summary for 7OE6

• Entry DOI: 10.2210/pdb7oe6/pdb
• Related: 7OE4 7OE5
• Descriptor: Bromodomain-containing protein 2, 2N-methyl-4N-(4-oxidanylcyclohexyl)-5-[(1S)-1-phenylethyl]furan-2,4-dicarboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: inhibitor, bromodomain, nuclear protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 13927.04

Authors

Chung, C. (deposition date: 2021-05-01, release date: 2021-07-28, Last modification date: 2021-08-25)

• Primary citation: Seal, J.T.,Atkinson, S.J.,Bamborough, P.,Bassil, A.,Chung, C.W.,Foley, J.,Gordon, L.,Grandi, P.,Gray, J.R.J.,Harrison, L.A.,Kruger, R.G.,Matteo, J.J.,McCabe, M.T.,Messenger, C.,Mitchell, D.,Phillipou, A.,Preston, A.,Prinjha, R.K.,Rianjongdee, F.,Rioja, I.,Taylor, S.,Wall, I.D.,Watson, R.J.,Woolven, J.M.,Wyce, A.,Zhang, X.P.,Demont, E.H.; Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors.; J.Med.Chem., 64:10772-10805, 2021; PubMed: 34255512; DOI: 10.1021/acs.jmedchem.1c00365

Experimental method

X-RAY DIFFRACTION (1.762 Å)