7OE8
C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH N5-((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-3-(1H-indol-4-yl)-N7-methyl-2,3-dihydrobenzofuran-5,7-dicarboxamide
Summary for 7OE8
Entry DOI | 10.2210/pdb7oe8/pdb |
Descriptor | Bromodomain-containing protein 2, 1,2-ETHANEDIOL, (3S)-3-(1H-indol-4-yl)-N7-methyl-N5-[(1R,5S)-3-oxabicyclo[3.1.0]hexan-6-yl]-2,3-dihydro-1-benzofuran-5,7-dicarboxamide, ... (4 entities in total) |
Functional Keywords | inhibitor, bromodomain, nuclear protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 13974.06 |
Authors | Chung, C. (deposition date: 2021-05-02, release date: 2021-07-28, Last modification date: 2024-05-01) |
Primary citation | Lucas, S.C.C.,Atkinson, S.J.,Chung, C.W.,Davis, R.,Gordon, L.,Grandi, P.,Gray, J.J.R.,Grimes, T.,Phillipou, A.,Preston, A.G.,Prinjha, R.K.,Rioja, I.,Taylor, S.,Tomkinson, N.C.O.,Wall, I.,Watson, R.J.,Woolven, J.,Demont, E.H. Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors. J.Med.Chem., 64:10711-10741, 2021 Cited by PubMed: 34260229DOI: 10.1021/acs.jmedchem.1c00344 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.301 Å) |
Structure validation
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