7OAT

Structural basis for targeted p97 remodelling by ASPL as prerequisite for p97 trimethylation by METTL21D

7OAT の概要

• エントリーDOI: 10.2210/pdb7oat/pdb
• 分子名称: Tether containing UBX domain for GLUT4, Transitional endoplasmic reticulum ATPase, Protein-lysine methyltransferase METTL21D, ... (8 entities in total)
• 機能のキーワード: p97, aaa+ atpase, aspl, mettl21d, vcp-kmt, vcp, methylation, remodelling, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 101509.79

構造登録者

Petrovic, S.,Heinemann, U.,Roske, Y. (登録日: 2021-04-20, 公開日: 2022-08-03, 最終更新日: 2024-02-07)

• 主引用文献: Petrovic, S.,Roske, Y.,Rami, B.,Phan, M.H.Q.,Panakova, D.,Heinemann, U.; Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D.; Proc.Natl.Acad.Sci.USA, 120:e2208941120-e2208941120, 2023; PubMed: 36656859; DOI: 10.1073/pnas.2208941120

実験手法

X-RAY DIFFRACTION (2.995 Å)