Summary for 7O6X
Entry DOI | 10.2210/pdb7o6x/pdb |
Descriptor | Poly [ADP-ribose] polymerase tankyrase-2, N-[3-[5-(5-ethoxypyridin-2-yl)-4-(2-fluorophenyl)-1,2,4-triazol-3-yl]cyclobutyl]quinoxaline-5-carboxamide, ZINC ION, ... (5 entities in total) |
Functional Keywords | inhibitor, complex, poly-adp-ribosylation, enzyme, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 50842.07 |
Authors | Sowa, S.T.,Lehtio, L. (deposition date: 2021-04-12, release date: 2022-01-12, Last modification date: 2024-01-31) |
Primary citation | Leenders, R.G.G.,Brinch, S.A.,Sowa, S.T.,Amundsen-Isaksen, E.,Galera-Prat, A.,Murthy, S.,Aertssen, S.,Smits, J.N.,Nieczypor, P.,Damen, E.,Wegert, A.,Nazare, M.,Lehtio, L.,Waaler, J.,Krauss, S. Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II. J.Med.Chem., 64:17936-17949, 2021 Cited by PubMed: 34878777DOI: 10.1021/acs.jmedchem.1c01264 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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