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7O6X

Tankyrase 2 in complex with an inhibitor (OM-153)

This is a non-PDB format compatible entry.
Summary for 7O6X
Entry DOI10.2210/pdb7o6x/pdb
DescriptorPoly [ADP-ribose] polymerase tankyrase-2, N-[3-[5-(5-ethoxypyridin-2-yl)-4-(2-fluorophenyl)-1,2,4-triazol-3-yl]cyclobutyl]quinoxaline-5-carboxamide, ZINC ION, ... (5 entities in total)
Functional Keywordsinhibitor, complex, poly-adp-ribosylation, enzyme, transferase
Biological sourceHomo sapiens (human)
More
Total number of polymer chains4
Total formula weight50842.07
Authors
Sowa, S.T.,Lehtio, L. (deposition date: 2021-04-12, release date: 2022-01-12, Last modification date: 2024-01-31)
Primary citationLeenders, R.G.G.,Brinch, S.A.,Sowa, S.T.,Amundsen-Isaksen, E.,Galera-Prat, A.,Murthy, S.,Aertssen, S.,Smits, J.N.,Nieczypor, P.,Damen, E.,Wegert, A.,Nazare, M.,Lehtio, L.,Waaler, J.,Krauss, S.
Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II.
J.Med.Chem., 64:17936-17949, 2021
Cited by
PubMed: 34878777
DOI: 10.1021/acs.jmedchem.1c01264
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

217705

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