7O2L

Yeast 20S proteasome in complex with the covalently bound inhibitor b-lactone (2R,3S)-3-isopropyl-4-oxo-2-oxetane-carboxylate (IOC)

Summary for 7O2L

• Entry DOI: 10.2210/pdb7o2l/pdb
• Related: 3E47
• Descriptor: HLJ1_G0039880.mRNA.1.CDS.1, Proteasome subunit beta, Proteasome subunit beta type-5, ... (18 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, proteasome, b-lactone, binding analysis, hydrolase
• Biological source: Saccharomyces cerevisiae (Baker's yeast); More
• Total number of polymer chains: 28
• Total formula weight: 732277.12

Authors

Shi, Y.M.,Hirschmann, M.,Shi, Y.N.,Shabbir, A.,Abebew, D.,Tobias, N.J.,Gruen, P.,Crames, J.J.,Poeschel, L.,Kuttenlochner, W.,Richter, C.,Herrmann, J.,Mueller, R.,Thanwisai, A.,Pidot, S.J.,Stinear, T.P.,Groll, M.,Kim, Y.,Bode, H. (deposition date: 2021-03-30, release date: 2022-04-13, Last modification date: 2024-01-31)

• Primary citation: Shi, Y.M.,Hirschmann, M.,Shi, Y.N.,Ahmed, S.,Abebew, D.,Tobias, N.J.,Grun, P.,Crames, J.J.,Poschel, L.,Kuttenlochner, W.,Richter, C.,Herrmann, J.,Muller, R.,Thanwisai, A.,Pidot, S.J.,Stinear, T.P.,Groll, M.,Kim, Y.,Bode, H.B.; Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria.; Nat.Chem., 14:701-712, 2022; PubMed: 35469007; DOI: 10.1038/s41557-022-00923-2

Experimental method

X-RAY DIFFRACTION (3 Å)