7O2F

Crystal structure of the human METTL3-METTL14 complex bound to Compound 22 (UZH2)

Summary for 7O2F

Entry DOI	10.2210/pdb7o2f/pdb
Descriptor	N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2,5-bis(fluoranyl)phenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one, ... (5 entities in total)
Functional Keywords	mettl3, inhibitor, complex, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	62338.00
Authors	Bedi, R.K.,Dolbois, A.,Caflisch, A. (deposition date: 2021-03-30, release date: 2021-09-01, Last modification date: 2024-01-31)
Primary citation	Dolbois, A.,Bedi, R.K.,Bochenkova, E.,Muller, A.,Moroz-Omori, E.V.,Huang, D.,Caflisch, A. 1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors. J.Med.Chem., 64:12738-12760, 2021 Cited by PubMed: 34431664 DOI: 10.1021/acs.jmedchem.1c00773 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation