7O27

Crystal structure of the human METTL3-METTL14 complex bound to Compound 17 (ADO_AE_005)

Summary for 7O27

• Entry DOI: 10.2210/pdb7o27/pdb
• Descriptor: N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,4,9-triazaspiro[5.5]undecan-2-one, ... (5 entities in total)
• Functional Keywords: mettl3, inhibitor, complex, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 62312.01

Authors

Bedi, R.K.,Dolbois, A.,Caflisch, A. (deposition date: 2021-03-30, release date: 2021-09-15, Last modification date: 2024-01-31)

• Primary citation: Bedi, R.K.,Dolbois, A.,Caflisch, A.; Crystal structure of the human METTL3-METTL14 complex bound to Compound 17 (ADO_AE_005); To Be Published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)