7NZE

Crystal structure of HLA-DR4 in complex with a human collagen type II peptide

This is a non-PDB format compatible entry.

Summary for 7NZE

• Entry DOI: 10.2210/pdb7nze/pdb
• Descriptor: HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen DR beta chain, Collagen alpha-1(II) chain, ... (6 entities in total)
• Functional Keywords: complex, mhcii, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 91160.95

Authors

Ge, C.,Dobritzsch, D.,Holmdahl, R. (deposition date: 2021-03-24, release date: 2022-06-08, Last modification date: 2024-01-31)

Primary citation

Ge, C.,Weisse, S.,Xu, B.,Dobritzsch, D.,Viljanen, J.,Kihlberg, J.,Do, N.N.,Schneider, N.,Lanig, H.,Holmdahl, R.,Burkhardt, H.
Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor.
Ann Rheum Dis, 81:480-489, 2022

PubMed Abstract: Rheumatoid arthritis (RA) is an autoimmune disease strongly associated with the major histocompatibility complex (MHC) class II allele DRB1*04:01, which encodes a protein that binds self-peptides for presentation to T cells. This study characterises the autoantigen-presenting function of DRB1*04:01 (HLA-DRA*01:01/HLA-DRB1*04:01) at a molecular level for prototypic T-cell determinants, focusing on a post-translationally modified collagen type II (Col2)-derived peptide.

PubMed: 35027402
DOI: 10.1136/annrheumdis-2021-220500

Experimental method

X-RAY DIFFRACTION (2.05 Å)