7NQ3

C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH N4-((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-6-((S)-methoxy(phenyl)methyl)-N2-methylpyridine-2,4-dicarboxamide

This is a non-PDB format compatible entry.

Summary for 7NQ3

• Entry DOI: 10.2210/pdb7nq3/pdb
• Related: 7NPY 7NPZ 7NQ0 7NQ1 7NQ2
• Descriptor: Bromodomain-containing protein 2, 1,2-ETHANEDIOL, 6-[(~{S})-methoxy(phenyl)methyl]-~{N}2-methyl-~{N}4-[(1~{S},5~{R})-3-oxabicyclo[3.1.0]hexan-6-yl]pyridine-2,4-dicarboxamide, ... (4 entities in total)
• Functional Keywords: inhibitor, histone, epigenetic reader, bromodomain, brd2, bromodomain containing protein 2, antagonist, nuclear protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 14000.09

Authors

Chung, C. (deposition date: 2021-02-28, release date: 2021-07-21, Last modification date: 2021-08-25)

• Primary citation: Harrison, L.A.,Atkinson, S.J.,Bassil, A.,Chung, C.W.,Grandi, P.,Gray, J.R.J.,Levernier, E.,Lewis, A.,Lugo, D.,Messenger, C.,Michon, A.M.,Mitchell, D.J.,Preston, A.,Prinjha, R.K.,Rioja, I.,Seal, J.T.,Taylor, S.,Wall, I.D.,Watson, R.J.,Woolven, J.M.,Demont, E.H.; Identification of a Series of N -Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins.; J.Med.Chem., 64:10742-10771, 2021; PubMed: 34232650; DOI: 10.1021/acs.jmedchem.0c02155

Experimental method

X-RAY DIFFRACTION (1.603 Å)