7NPZ
C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH (R)-N5-cyclopropyl-N3-methyl-2-oxo-1-(1-phenylethyl)-1,2-dihydropyridine-3,5-dicarboxamide
This is a non-PDB format compatible entry.
Summary for 7NPZ
Entry DOI | 10.2210/pdb7npz/pdb |
Related | 7NPY |
Descriptor | Bromodomain-containing protein 2, 1,2-ETHANEDIOL, ~{N}5-cyclopropyl-~{N}3-methyl-2-oxidanylidene-1-[(1~{R})-1-phenylethyl]pyridine-3,5-dicarboxamide, ... (4 entities in total) |
Functional Keywords | inhibitor, histone, epigenetic reader, bromodomain, brd2, bromodomain containing protein 2, antagonist, nuclear protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 13958.05 |
Authors | Chung, C. (deposition date: 2021-02-28, release date: 2021-07-21, Last modification date: 2024-05-01) |
Primary citation | Harrison, L.A.,Atkinson, S.J.,Bassil, A.,Chung, C.W.,Grandi, P.,Gray, J.R.J.,Levernier, E.,Lewis, A.,Lugo, D.,Messenger, C.,Michon, A.M.,Mitchell, D.J.,Preston, A.,Prinjha, R.K.,Rioja, I.,Seal, J.T.,Taylor, S.,Wall, I.D.,Watson, R.J.,Woolven, J.M.,Demont, E.H. Identification of a Series of N -Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins. J.Med.Chem., 64:10742-10771, 2021 Cited by PubMed: 34232650DOI: 10.1021/acs.jmedchem.0c02155 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.28 Å) |
Structure validation
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