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7NQ2

C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH (S)-N4-cyclopropyl-N2-methyl-6-(1-phenylethyl)pyridine-2,4-dicarboxamide

This is a non-PDB format compatible entry.
Summary for 7NQ2
Entry DOI10.2210/pdb7nq2/pdb
Related7NPY 7NPZ
DescriptorBromodomain-containing protein 2, ~{N}4-cyclopropyl-~{N}2-methyl-6-[(1~{S})-1-phenylethyl]pyridine-2,4-dicarboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsinhibitor, histone, epigenetic reader, bromodomain, brd2, bromodomain containing protein 2, antagonist, nuclear protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight13879.99
Authors
Chung, C. (deposition date: 2021-02-28, release date: 2021-07-21, Last modification date: 2021-08-25)
Primary citationHarrison, L.A.,Atkinson, S.J.,Bassil, A.,Chung, C.W.,Grandi, P.,Gray, J.R.J.,Levernier, E.,Lewis, A.,Lugo, D.,Messenger, C.,Michon, A.M.,Mitchell, D.J.,Preston, A.,Prinjha, R.K.,Rioja, I.,Seal, J.T.,Taylor, S.,Wall, I.D.,Watson, R.J.,Woolven, J.M.,Demont, E.H.
Identification of a Series of N -Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins.
J.Med.Chem., 64:10742-10771, 2021
Cited by
PubMed: 34232650
DOI: 10.1021/acs.jmedchem.0c02155
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.735 Å)
Structure validation

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