7NOY

Crystal structure of the heterocyclic toxin methyltransferase from Mycobacterium tuberculosis in complex with substrate 1-hydroxyquinolin-4(1H)-one

Summary for 7NOY

Entry DOI	10.2210/pdb7noy/pdb
Descriptor	Uncharacterized protein Rv0560c, S-ADENOSYL-L-HOMOCYSTEINE, 1-oxidanylquinolin-4-one, ... (5 entities in total)
Functional Keywords	methyltransferase, hqno-detoxification, sam-dependent, transferase
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	1
Total formula weight	27035.02
Authors	Denkhaus, L.,Sartor, P.,Einsle, O.,Gerhardt, S.,Fetzner, S. (deposition date: 2021-02-26, release date: 2021-09-22, Last modification date: 2024-01-31)
Primary citation	Sartor, P.,Denkhaus, L.,Gerhardt, S.,Einsle, O.,Fetzner, S. Structural basis of O-methylation of (2-heptyl-)1-hydroxyquinolin-4(1H)-one and related compounds by the heterocyclic toxin methyltransferase Rv0560c of Mycobacterium tuberculosis. J.Struct.Biol., 213:107794-107794, 2021 Cited by PubMed: 34506908 DOI: 10.1016/j.jsb.2021.107794 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation