7NMU

Crystal structure of human platelet glycoprotein VI in complex with an inhibitory nanobody.

This is a non-PDB format compatible entry.

Summary for 7NMU

• Entry DOI: 10.2210/pdb7nmu/pdb
• Descriptor: Platelet glycoprotein VI, Nanobody 2, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: nanobody, complex, domain-swap, blood clotting
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 71123.59

Authors

Slater, A.,Jonas, E.,Watson, S.P. (deposition date: 2021-02-23, release date: 2021-03-10, Last modification date: 2024-01-31)

• Primary citation: Slater, A.,Di, Y.,Clark, J.C.,Jooss, N.J.,Martin, E.M.,Alenazy, F.,Thomas, M.R.,Ariens, R.A.S.,Herr, A.B.,Poulter, N.S.,Emsley, J.,Watson, S.P.; Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer.; Blood, 137:3443-3453, 2021; PubMed: 33512486; DOI: 10.1182/blood.2020009440

Experimental method

X-RAY DIFFRACTION (2.5 Å)