7NG7

Src kinase bound to eCF506 trapped in inactive conformation

Summary for 7NG7

• Entry DOI: 10.2210/pdb7ng7/pdb
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, 1,2-ETHANEDIOL, tert-butyl (4-(4-amino-1-(2-(4-(dimethylamino)piperidin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl)carbamate, ... (4 entities in total)
• Functional Keywords: src kinase, inhibitor complex, inactive kinase, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 33329.26

Authors

Lietha, D.,Unciti-Broceta, A. (deposition date: 2021-02-08, release date: 2021-09-15, Last modification date: 2024-01-31)

• Primary citation: Temps, C.,Lietha, D.,Webb, E.R.,Li, X.F.,Dawson, J.C.,Muir, M.,Macleod, K.G.,Valero, T.,Munro, A.F.,Contreras-Montoya, R.,Luque-Ortega, J.R.,Fraser, C.,Beetham, H.,Schoenherr, C.,Lopalco, M.,Arends, M.J.,Frame, M.C.,Qian, B.Z.,Brunton, V.G.,Carragher, N.O.,Unciti-Broceta, A.; A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability.; Cancer Res., 81:5438-5450, 2021; PubMed: 34417202; DOI: 10.1158/0008-5472.CAN-21-0613

Experimental method

X-RAY DIFFRACTION (1.5 Å)