7NG7
Src kinase bound to eCF506 trapped in inactive conformation
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 601 |
| Chain | Residue |
| A | ILE429 |
| A | THR432 |
| A | PRO434 |
| A | ALA437 |
| A | VAL474 |
| A | HOH744 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue UCW A 602 |
| Chain | Residue |
| A | ILE339 |
| A | THR341 |
| A | GLU342 |
| A | MET344 |
| A | GLY347 |
| A | ASP351 |
| A | LEU396 |
| A | ASP407 |
| A | PHE408 |
| A | HOH822 |
| A | HOH844 |
| A | LEU276 |
| A | ALA296 |
| A | LYS298 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 23 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGCFGEVWmGtwngttr...........VAIK |
| Chain | Residue | Details |
| A | LEU276-LYS298 |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YVHrDLRAANILV |
| Chain | Residue | Details |
| A | TYR385-VAL397 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by FAK2","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by CSK","evidences":[{"source":"PubMed","id":"19307596","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26936507","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7525268","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7929427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
