7NG7
Src kinase bound to eCF506 trapped in inactive conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Proto-oncogene tyrosine-protein kinase Src | polymer | 287 | 32756.6 | 1 | UniProt (P12931) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-Src,pp60c-src,p60-Src |
| 2 | B (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 3 | C (A) | tert-butyl (4-(4-amino-1-(2-(4-(dimethylamino)piperidin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl)carbamate | non-polymer | 510.6 | 1 | Chemie (UCW) | |||
| 4 | D (A) | water | water | 18.0 | 223 | Chemie (HOH) |
Sequence modifications
A: 254 - 536 (UniProt: P12931)
| PDB | External Database | Details |
|---|---|---|
| Gly 250 | - | expression tag |
| Ser 251 | - | expression tag |
| Asp 252 | - | expression tag |
| Ile 253 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32756.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 572.7 | |
| All* | Total formula weight | 33329.3 |
