7NFC

Cryo-EM structure of NHEJ super-complex (dimer)

7NFC の概要

• エントリーDOI: 10.2210/pdb7nfc/pdb
• EMDBエントリー: 12299
• 分子名称: DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-PKcs, X-ray repair cross-complementing protein 6, X-ray repair cross-complementing protein 5, ... (9 entities in total)
• 機能のキーワード: nhej, dna-pkcs, ku70/80, xlf, xrcc4, dna-ligaseiv, dna binding protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 18
• 化学式量合計: 1710536.03

構造登録者

Chaplin, A.K.,Hardwick, S.W.,Kefala Stavridi, A.,Chirgadze, D.Y.,Blundell, T.L. (登録日: 2021-02-05, 公開日: 2021-08-18, 最終更新日: 2024-07-10)

• 主引用文献: Chaplin, A.K.,Hardwick, S.W.,Stavridi, A.K.,Buehl, C.J.,Goff, N.J.,Ropars, V.,Liang, S.,De Oliveira, T.M.,Chirgadze, D.Y.,Meek, K.,Charbonnier, J.B.,Blundell, T.L.; Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.; Mol.Cell, 81:3400-3409, 2021; PubMed: 34352203; DOI: 10.1016/j.molcel.2021.07.005

実験手法

ELECTRON MICROSCOPY (4.14 Å)