7NE1

Structure of the complex between Netrin-1 and its receptor Neogenin

7NE1 の概要

• エントリーDOI: 10.2210/pdb7ne1/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900013
• 分子名称: Netrin-1, Neogenin, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: cell surface receptor signaling, axon guidance, migration, cancer, growth cone, receptor clustering, netrin, neogenin, repulsive guidance molecule, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 90962.75

構造登録者

Robinson, R.A.,Griffiths, S.C.,van de Haar, L.L.,Malinauskas, T.,van Battum, E.Y.,Zelina, P.,Schwab, R.A.,Karia, D.,Malinauskaite, L.,Brignani, S.,van den Munkhof, M.,Dudukcu, O.,De Ruiter, A.A.,Van den Heuvel, D.M.A.,Bishop, B.,Elegheert, J.,Aricescu, A.R.,Pasterkamp, R.J.,Siebold, C. (登録日: 2021-02-02, 公開日: 2021-03-31, 最終更新日: 2024-01-31)

• 主引用文献: Robinson, R.A.,Griffiths, S.C.,van de Haar, L.L.,Malinauskas, T.,van Battum, E.Y.,Zelina, P.,Schwab, R.A.,Karia, D.,Malinauskaite, L.,Brignani, S.,van den Munkhof, M.H.,Dudukcu, O.,De Ruiter, A.A.,Van den Heuvel, D.M.A.,Bishop, B.,Elegheert, J.,Aricescu, A.R.,Pasterkamp, R.J.,Siebold, C.; Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.; Cell, 184:2103-, 2021; PubMed: 33740419; DOI: 10.1016/j.cell.2021.02.045

実験手法

X-RAY DIFFRACTION (3.15 Å)