7NBS

Crystal structure of SARS-CoV-2 main protease (Mpro) in complex with the HCV NS3/4A inhibitor telaprevir

This is a non-PDB format compatible entry.

Summary for 7NBS

• Entry DOI: 10.2210/pdb7nbs/pdb
• Related PRD ID: PRD_002448
• Descriptor: 3C-like proteinase, CHLORIDE ION, (1S,3aR,6aS)-2-[(2S)-2-({(2S)-2-cyclohexyl-2-[(pyrazin-2-ylcarbonyl)amino]acetyl}amino)-3,3-dimethylbutanoyl]-N-[(2R,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl]octahydrocyclopenta[c]pyrrole-1-carboxamide, ... (4 entities in total)
• Functional Keywords: coronavirus, main protease, drug repurposing, hepatitis c virus, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
• Total number of polymer chains: 1
• Total formula weight: 34542.86

Authors

Zhang, L.,Hilgenfeld, R. (deposition date: 2021-01-27, release date: 2021-03-03, Last modification date: 2024-01-31)

• Primary citation: Zhang, L.,Hilgenfeld, R.; Crystal structure of SARS-CoV-2 main protease (Mpro) in complex with the HCV NS3/4A inhibitor boceprevir; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)