7N9G
Crystal structure of the Abl 1b Kinase domain in complex with Dasatinib and Imatinib
Summary for 7N9G
Entry DOI | 10.2210/pdb7n9g/pdb |
Descriptor | Tyrosine-protein kinase ABL1, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, ... (5 entities in total) |
Functional Keywords | abl kinase, kinase allosteric regulation, drug resistance, cell cycle |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 97516.01 |
Authors | Miller, D.J.,Xie, T. (deposition date: 2021-06-17, release date: 2022-04-27, Last modification date: 2023-10-18) |
Primary citation | Xie, T.,Saleh, T.,Rossi, P.,Miller, D.,Kalodimos, C.G. Imatinib can act as an Allosteric Activator of Abl Kinase. J.Mol.Biol., 434:167349-167349, 2022 Cited by PubMed: 34774565DOI: 10.1016/j.jmb.2021.167349 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report