7N9G

Crystal structure of the Abl 1b Kinase domain in complex with Dasatinib and Imatinib

Summary for 7N9G

Entry DOI	10.2210/pdb7n9g/pdb
Descriptor	Tyrosine-protein kinase ABL1, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, ... (5 entities in total)
Functional Keywords	abl kinase, kinase allosteric regulation, drug resistance, cell cycle
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	97516.01
Authors	Miller, D.J.,Xie, T. (deposition date: 2021-06-17, release date: 2022-04-27, Last modification date: 2023-10-18)
Primary citation	Xie, T.,Saleh, T.,Rossi, P.,Miller, D.,Kalodimos, C.G. Imatinib can act as an Allosteric Activator of Abl Kinase. J.Mol.Biol., 434:167349-167349, 2022 Cited by PubMed: 34774565 DOI: 10.1016/j.jmb.2021.167349 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation