7N9G
Crystal structure of the Abl 1b Kinase domain in complex with Dasatinib and Imatinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Tyrosine-protein kinase ABL1 | polymer | 271 | 31492.1 | 3 | UniProt (P00519) Pfam (PF07714) | Homo sapiens (Human) | Abelson murine leukemia viral oncogene homolog 1,Abelson tyrosine-protein kinase 1,Proto-oncogene c-Abl,p150 |
| 2 | D, G, I (A, B, C) | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE | non-polymer | 493.6 | 3 | Chemie (STI) | |||
| 3 | E, H, J (A, B, C) | N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE | non-polymer | 488.0 | 3 | Chemie (1N1) | |||
| 4 | F (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 5 | K, L, M (A, B, C) | water | water | 18.0 | 206 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 94476.2 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 3039.8 | |
| All* | Total formula weight | 97516.0 |
