7N6X

Crystal structure of HIV-1 Protease multiple mutants PRS17 bound to inhibitor Amprenavir

Summary for 7N6X

• Entry DOI: 10.2210/pdb7n6x/pdb
• Related: 5T2E 5T2Z 6O54 6O57 6O5A 6O5X
• Descriptor: Protease, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER (3 entities in total)
• Functional Keywords: drug resistance, prs17, hydrolase
• Biological source: Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1)
• Total number of polymer chains: 2
• Total formula weight: 22090.92

Authors

Burnaman, S.H.,Wang, Y.-F.,Weber, I.T. (deposition date: 2021-06-09, release date: 2021-09-08, Last modification date: 2023-10-18)

• Primary citation: Burnaman, S.H.,Kneller, D.W.,Wang, Y.F.,Kovalevsky, A.,Weber, I.T.; Revertant mutation V48G alters conformational dynamics of highly drug resistant HIV protease PRS17.; J.Mol.Graph.Model., 108:108005-108005, 2021; PubMed: 34419931; DOI: 10.1016/j.jmgm.2021.108005

Experimental method

X-RAY DIFFRACTION (1.47 Å)