7N6X
Crystal structure of HIV-1 Protease multiple mutants PRS17 bound to inhibitor Amprenavir
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Protease | polymer | 99 | 10792.6 | 2 | UniProt (P03367) Pfam (PF00077) In PDB | Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) | PR,Retropepsin |
2 | B | {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER | non-polymer | 505.6 | 1 | Chemie (478) | |||
3 | water | water | 18.0 | 53 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03367)
PDB | External Database | Details |
---|---|---|
Lys 7 | Gln 507 | engineered mutation |
Ile 10 | Leu 510 | engineered mutation |
Arg 20 | Lys 520 | engineered mutation |
Asp 35 | Glu 535 | engineered mutation |
Ile 36 | Met 536 | engineered mutation |
Asp 37 | Ser 537 | engineered mutation |
Leu 46 | Met 546 | engineered mutation |
Val 48 | Gly 548 | engineered mutation |
Val 54 | Ile 554 | engineered mutation |
Glu 60 | Asp 560 | engineered mutation |
Val 62 | Ile 562 | engineered mutation |
Pro 63 | Leu 563 | engineered mutation |
Ala 67 | Cys 567 | engineered mutation |
Val 71 | Ala 571 | engineered mutation |
Val 72 | Ile 572 | engineered mutation |
Ile 77 | Val 577 | engineered mutation |
Ser 82 | Val 582 | engineered mutation |
Met 90 | Leu 590 | engineered mutation |
Leu 93 | Ile 593 | engineered mutation |
Ala 95 | Cys 595 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 21585.3 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 505.6 | |
All* | Total formula weight | 22090.9 |