7N6V
Crystal structure of HIV-1 Protease multiple mutants PRS17 with Revertant mutation V48G bound to inhibitor Amprenavir
Summary for 7N6V
Entry DOI | 10.2210/pdb7n6v/pdb |
Related | 5T2E 5T2Z 6O54 6O57 6O5A 6O5X |
Descriptor | Protease, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER, GLYCEROL, ... (4 entities in total) |
Functional Keywords | hiv-1 protease, drug resistance, prs17, hydrolase |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) |
Total number of polymer chains | 2 |
Total formula weight | 22190.94 |
Authors | Burnaman, S.H.,Wang, Y.-F.,Weber, I.T. (deposition date: 2021-06-09, release date: 2021-09-08, Last modification date: 2023-10-18) |
Primary citation | Burnaman, S.H.,Kneller, D.W.,Wang, Y.F.,Kovalevsky, A.,Weber, I.T. Revertant mutation V48G alters conformational dynamics of highly drug resistant HIV protease PRS17. J.Mol.Graph.Model., 108:108005-108005, 2021 Cited by PubMed: 34419931DOI: 10.1016/j.jmgm.2021.108005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.39 Å) |
Structure validation
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