7N3T

TrkA ECD complex with designed miniprotein ligand

Summary for 7N3T

• Entry DOI: 10.2210/pdb7n3t/pdb
• Related: 7N1J 7N1K 7OPB
• Descriptor: High affinity nerve growth factor receptor, Designed TrkA-binding miniprotein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: complex, de novo protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 103403.85

Authors

Jude, K.M.,Cao, L.,Garcia, K.C. (deposition date: 2021-06-01, release date: 2022-04-20, Last modification date: 2023-10-18)

• Primary citation: Cao, L.,Coventry, B.,Goreshnik, I.,Huang, B.,Sheffler, W.,Park, J.S.,Jude, K.M.,Markovic, I.,Kadam, R.U.,Verschueren, K.H.G.,Verstraete, K.,Walsh, S.T.R.,Bennett, N.,Phal, A.,Yang, A.,Kozodoy, L.,DeWitt, M.,Picton, L.,Miller, L.,Strauch, E.M.,DeBouver, N.D.,Pires, A.,Bera, A.K.,Halabiya, S.,Hammerson, B.,Yang, W.,Bernard, S.,Stewart, L.,Wilson, I.A.,Ruohola-Baker, H.,Schlessinger, J.,Lee, S.,Savvides, S.N.,Garcia, K.C.,Baker, D.; Design of protein-binding proteins from the target structure alone.; Nature, 605:551-560, 2022; PubMed: 35332283; DOI: 10.1038/s41586-022-04654-9

Experimental method

X-RAY DIFFRACTION (1.84 Å)