7N3T
TrkA ECD complex with designed miniprotein ligand
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | High affinity nerve growth factor receptor | polymer | 359 | 39318.3 | 2 | UniProt (P04629) Pfam (PF16920) In PDB | Homo sapiens (Human) | Neurotrophic tyrosine kinase receptor type 1,TRK1-transforming tyrosine kinase protein,Tropomyosin-related kinase A,Tyrosine kinase receptor,Tyrosine kinase receptor A,Trk-A,gp140trk,p140-TrkA |
2 | C, D | Designed TrkA-binding miniprotein | polymer | 81 | 9570.1 | 2 | Synthetic construct | ||
3 | E | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
4 | F | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
5 | B, A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 14 | Chemie (NAG) | |||
6 | B, A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
7 | B, A | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
8 | water | water | 18.0 | 260 | Chemie (HOH) |
Sequence modifications
A, B: 36 - 382 (UniProt: P04629)
PDB | External Database | Details |
---|---|---|
Ser 35 | - | expression tag |
Leu 263 | Val 263 | conflict |
Ala 383 | - | expression tag |
Ala 384 | - | expression tag |
Ala 385 | - | expression tag |
His 386 | - | expression tag |
His 387 | - | expression tag |
His 388 | - | expression tag |
His 389 | - | expression tag |
His 390 | - | expression tag |
His 391 | - | expression tag |
His 392 | - | expression tag |
His 393 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 97776.8 | |
Branched | Number of molecules | 2 |
Total formula weight | 1010.9 | |
Non-Polymers* | Number of molecules | 33 |
Total formula weight | 4616.2 | |
All* | Total formula weight | 103403.9 |