7N0A

Structure of Human Leukaemia Inhibitory Factor with Fab MSC1

Summary for 7N0A

• Entry DOI: 10.2210/pdb7n0a/pdb
• Descriptor: Leukemia inhibitory factor, MSC-1 Fab Light chain, MSC-1 Fab Heavy chain, ... (7 entities in total)
• Functional Keywords: lif, cytokine, antibody, cancer therapeutics, cytokine-immune system complex, cytokine/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 69317.99

Authors

Raman, S.,Bosch, A.,Fransson, J.,Julien, J.P. (deposition date: 2021-05-25, release date: 2022-06-15, Last modification date: 2024-10-09)

Primary citation

Hallett, R.M.,Bonfill-Teixidor, E.,Iurlaro, R.,Arias, A.,Raman, S.,Bayliss, P.,Egorova, O.,Neva-Alejo, A.,McGray, A.R.,Lau, E.,Bosch, A.,Beilschmidt, M.,Maetzel, D.,Fransson, J.,Huber-Ruano, I.,Anido, J.,Julien, J.P.,Giblin, P.,Seoane, J.
Therapeutic Targeting of LIF Overcomes Macrophage-mediated Immunosuppression of the Local Tumor Microenvironment.
Clin.Cancer Res., 29:791-804, 2023

PubMed Abstract: Leukemia inhibitory factor (LIF) is a multifunctional cytokine with numerous reported roles in cancer and is thought to drive tumor development and progression. Characterization of LIF and clinical-stage LIF inhibitors would increase our understanding of LIF as a therapeutic target.

PubMed: 36441800
DOI: 10.1158/1078-0432.CCR-21-1888

Experimental method

X-RAY DIFFRACTION (3.1 Å)