7MY3

CryoEM structure of neutralizing nanobody Nb12 in complex with SARS-CoV2 spike

Summary for 7MY3

• Entry DOI: 10.2210/pdb7my3/pdb
• Related: 7MY2
• EMDB information: 24077 24078
• Descriptor: Spike glycoprotein, Nanobody Nb12, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: sars-cov2, nanobody, neutralizing, spike, immune system-viral protein complex, immune system/viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2, COVID-19 virus); More
• Total number of polymer chains: 6
• Total formula weight: 482308.93

Authors

Xu, K.,Kwong, P.D. (deposition date: 2021-05-20, release date: 2021-06-16, Last modification date: 2021-07-28)

• Primary citation: Xu, J.,Xu, K.,Jung, S.,Conte, A.,Lieberman, J.,Muecksch, F.,Lorenzi, J.C.C.,Park, S.,Schmidt, F.,Wang, Z.,Huang, Y.,Luo, Y.,Nair, M.S.,Wang, P.,Schulz, J.E.,Tessarollo, L.,Bylund, T.,Chuang, G.Y.,Olia, A.S.,Stephens, T.,Teng, I.T.,Tsybovsky, Y.,Zhou, T.,Munster, V.,Ho, D.D.,Hatziioannou, T.,Bieniasz, P.D.,Nussenzweig, M.C.,Kwong, P.D.,Casellas, R.; Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants.; Nature, 595:278-282, 2021; PubMed: 34098567; DOI: 10.1038/s41586-021-03676-z

Experimental method

ELECTRON MICROSCOPY (2.9 Å)