7MXI

IgE-Fc in complex with DARPins E2_79 and E3_53

7MXI の概要

• エントリーDOI: 10.2210/pdb7mxi/pdb
• 分子名称: IgE Fc, DARPin E3_53, Anti-IgE Inhibitor E2_79, ... (5 entities in total)
• 機能のキーワード: ige, darpin, allergy, inhibitor, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 125455.18

構造登録者

Pennington, L.F.,Jardetzky, T.J. (登録日: 2021-05-19, 公開日: 2021-07-28, 最終更新日: 2024-10-23)

主引用文献

Pennington, L.F.,Gasser, P.,Brigger, D.,Guntern, P.,Eggel, A.,Jardetzky, T.S.
Structure-guided design of ultrapotent disruptive IgE inhibitors to rapidly terminate acute allergic reactions.
J.Allergy Clin.Immunol., 148:1049-1060, 2021

PubMed Abstract: Anaphylaxis represents one of the most severe and fatal forms of allergic reactions. Like most other allergies, it is caused by activation of basophils and mast cells by allergen-mediated cross-linking of IgE bound to its high-affinity receptor, FcεRI, on the cell surface. The systemic release of soluble mediators induces an inflammatory cascade, rapidly causing symptoms with peak severity in minutes to hours after allergen exposure. Primary treatment for anaphylaxis consists of immediate intramuscular administration of adrenaline.

PubMed: 33991582
DOI: 10.1016/j.jaci.2021.03.050

実験手法

X-RAY DIFFRACTION (2.8 Å)