7MWN

An engineered PYL2-based WIN 55,212-2 synthetic cannabinoid sensor with a stabilized HAB1 variant

Summary for 7MWN

Entry DOI	10.2210/pdb7mwn/pdb
Descriptor	Abscisic acid receptor PYL2, HAB1-T+, {(3R)-5-methyl-3-[(morpholin-4-yl)methyl]-2,3-dihydro[1,4]oxazino[2,3,4-hi]indol-6-yl}(naphthalen-1-yl)methanone, ... (9 entities in total)
Functional Keywords	pyr/pyl/rcar, pyl2, hormone receptor, plant protein, biosensor, cannabinoid
Biological source	Arabidopsis thaliana (Mouse-ear cress) More
Total number of polymer chains	2
Total formula weight	58893.58
Authors	Peterson, F.C.,Beltran, J.,Bedewitz, M.,Steiner, P.J.,Cutler, S.R.,Whitehead, T.A. (deposition date: 2021-05-17, release date: 2022-06-01, Last modification date: 2023-10-25)
Primary citation	Beltran, J.,Steiner, P.J.,Bedewitz, M.,Wei, S.,Peterson, F.C.,Li, Z.,Hughes, B.E.,Hartley, Z.,Robertson, N.R.,Medina-Cucurella, A.V.,Baumer, Z.T.,Leonard, A.C.,Park, S.Y.,Volkman, B.F.,Nusinow, D.A.,Zhong, W.,Wheeldon, I.,Cutler, S.R.,Whitehead, T.A. Rapid biosensor development using plant hormone receptors as reprogrammable scaffolds. Nat.Biotechnol., 40:1855-1861, 2022 Cited by PubMed: 35726092 DOI: 10.1038/s41587-022-01364-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.902 Å)

Structure validation