7MWN
An engineered PYL2-based WIN 55,212-2 synthetic cannabinoid sensor with a stabilized HAB1 variant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Abscisic acid receptor PYL2 | polymer | 190 | 21246.8 | 1 | UniProt (O80992) Pfam (PF10604) In PDB | Arabidopsis thaliana (Mouse-ear cress) | PYR1-like protein 2,Regulatory components of ABA receptor 14 |
| 2 | B | HAB1-T+ | polymer | 333 | 36719.1 | 1 | Pfam (PF00481) UniProt (by SIFTS) (Q9CAJ0) In PDB | Arabidopsis thaliana | |
| 3 | A | {(3R)-5-methyl-3-[(morpholin-4-yl)methyl]-2,3-dihydro[1,4]oxazino[2,3,4-hi]indol-6-yl}(naphthalen-1-yl)methanone | non-polymer | 426.5 | 1 | Chemie (WI5) | |||
| 4 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 5 | A, B | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 6 | B | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 7 | B | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 8 | B | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 9 | water | water | 18.0 | 219 | Chemie (HOH) |
Sequence modifications
A: 1 - 190 (UniProt: O80992)
| PDB | External Database | Details |
|---|---|---|
| Gln 64 | Lys 64 | engineered mutation |
| Ala 165 | Phe 165 | engineered mutation |
| Ile 166 | Val 166 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 57965.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 927.7 | |
| All* | Total formula weight | 58893.6 |
