7MU3

human carbonic anhydrase 9 mimic with compound

Summary for 7MU3

• Entry DOI: 10.2210/pdb7mu3/pdb
• Descriptor: Carbonic anhydrase 2, ZINC ION, ethyl (8R)-7-methyl-3-({[(4-sulfamoylphenyl)methyl]carbamothioyl}amino)pyrazolo[1,5-a]pyrimidine-6-carboxylate, ... (7 entities in total)
• Functional Keywords: human carbonic anhydrase ii; drug discovery; privileged scaffolds, lyase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 30190.15

Authors

Peat, T.S. (deposition date: 2021-05-14, release date: 2021-08-25, Last modification date: 2023-10-18)

• Primary citation: Gumus, A.,Bozdag, M.,Angeli, A.,Peat, T.S.,Carta, F.,Supuran, C.T.,Selleri, S.; Privileged scaffolds in medicinal chemistry: Studies on pyrazolo[1,5-a]pyrimidines on sulfonamide containing Carbonic Anhydrase inhibitors.; Bioorg.Med.Chem.Lett., 49:128309-128309, 2021; PubMed: 34371130; DOI: 10.1016/j.bmcl.2021.128309

Experimental method

X-RAY DIFFRACTION (1.35 Å)