7MRZ

Structure of GDF11 bound to fused ActRIIB-ECD and Alk4-ECD with Anti-ActRIIB Fab fragment

7MRZ の概要

• エントリーDOI: 10.2210/pdb7mrz/pdb
• 分子名称: Growth/differentiation factor 11, Activin receptor type-2B,Activin receptor type-1B, Fab Heavy Chain, ... (6 entities in total)
• 機能のキーワード: growth factor, type i receptor, transforming growth factor beta, type ii receptor, ternary complex, gdf11, signaling protein, signaling protein-immune system complex, signaling protein/immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 88371.92

構造登録者

Goebel, E.J.,Kattamuri, C.,Gipson, G.R.,Thompson, T.B. (登録日: 2021-05-10, 公開日: 2022-01-19, 最終更新日: 2023-10-18)

• 主引用文献: Goebel, E.J.,Kattamuri, C.,Gipson, G.R.,Krishnan, L.,Chavez, M.,Czepnik, M.,Maguire, M.C.,Grenha, R.,Hakansson, M.,Logan, D.T.,Grinberg, A.V.,Sako, D.,Castonguay, R.,Kumar, R.,Thompson, T.B.; Structures of activin ligand traps using natural sets of type I and type II TGF beta receptors.; Iscience, 25:103590-103590, 2022; PubMed: 35005539; DOI: 10.1016/j.isci.2021.103590

実験手法

X-RAY DIFFRACTION (3 Å)